The ubiquitin-like protein NEDD8/Rub1 is initially translated as a precursor and undergoes maturation before becoming functional. a process mediated by the ubiquitin hydrolase UCHL3/Yuh1. Across studied organisms. the mature form of NEDD8/Rub1 modifies cullins. https://parisnaturalfoodes.shop/product-category/crab-apple/